ALK (anaplastic lymphoma kinase) gene

The ALK gene makes an ALK protein, which may be involved in cell growth. Mutations of the ALK gene and protein have been found in certain types of cancer, including non-small cell lung cancer.

ALK inhibitors

ALK inhibitors are medicines that bind to and stop the ALK fusion protein. This may help prevent the growth and spread of tumor cells.


ALK (anaplastic lymphoma kinase) metastatic non-small cell lung cancer is a type of lung cancer that has spread to other places in the body, involving the ALK gene.


Central nervous system

The central nervous system includes the brain and the spinal cord.

Complete response

The disappearance of all signs of cancer, such as tumors, in response to treatment. This does not mean the cancer has been cured. 


Duration of response

The amount of time from when tumors first start to shrink in response to a given treatment to the time when tumors begin to grow again.


Exploratory analysis

An assessment of study results that was not specifically designed to find differences between two treatments in a study.



The Food and Drug Administration, or FDA, is a US federal agency whose mission is to protect public health.



The median is the middle value, or number, in a set of measurements when arranged from least to greatest.


The spread of cancer from the place where it started to other places in the body.


Partial response

The decrease in the size and spread of tumors in response to a given treatment.

PFS (progression-free survival)

The length of time during and after cancer treatment when a patient lives with the disease without it getting worse.


A molecule that is needed for your body to function properly. Proteins are the basis of cells in your body, including ALK.



A type of research study, or clinical trial, that tests how well a new medicine works in people. Studies can test new methods of screening, prevention, diagnosis, or treatment of a disease